MNX1

Across TCGA patient cohorts, MNX1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MNX1-associated genes across cancer lineages are JNK_pT183_Y185, Cyclin-E2, and ERK2. Each is linked with MNX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MNX1-to-partner and partner-to-MNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MNX1-low versus MNX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MNX1→partner) and Y-score (partner→MNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.194	-3.169	.013	.019	3	2
UCEC	Cyclin-E2 →	+0.173	+2.817	.027	.036	3	2
UCEC	ERK2 →	+0.216	+3.000	.016	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-3.160	.032	.019	3	1
UCEC	INPP4B →	-0.345	-2.321	.022	.033	3	1
UCEC	Ku80 →	+0.244	+2.598	.026	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

JNK_pT183_Y185 by MNX1 expression — UCEC

Explore this box plot interactively →