Q-omics provides the consensus-scored MINDY3 profile across patient tissues and cancer cell-line models. MINDY3 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MINDY3 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, MINDY3 RNA expression shows 20,803 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, THCA, and ACC as cancer lineages where MINDY3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MINDY3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MINDY3 survival associations across molecular data types. MINDY3 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (6) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MINDY3 RNA expression–survival associations across cancer types. High MINDY3 expression shows unfavorable associations in ACC, CESC, SCLC and UVM, but favorable associations in KIRC and LGG. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for MINDY3 RNA expression.
This table summarizes MINDY3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 6. The strongest signals are observed in THCA for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for MINDY3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MINDY3 shows lower tumor expression in THCA, KICH, UCEC, BLCA, LUSC and LUAD. The THCA box plot shows higher MINDY3 RNA expression in normal versus tumor tissue (log2 FC = −0.622, t-test p < 0.001).
This table shows molecular features associated with MINDY3 in patient tissues and cancer cell lines. In patient samples, MINDY3 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, MINDY3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
