Q-omics provides the consensus-scored MED19 profile across patient tissues and cancer cell-line models. MED19 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MED19 is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, MED19 protein abundance shows 21,323 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, HNSC, and LSCC as cancer lineages where MED19 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MED19 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MED19 survival associations across molecular data types. MED19 RNA expression shows survival associations in the most cancer types (28), followed by mutation status (2) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MED19 RNA expression–survival associations across cancer types. High MED19 expression shows unfavorable associations in ACC, KICH, HNSC, LIHC and UVM, but favorable associations in OV. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for MED19 RNA expression.
This table summarizes MED19 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for MED19. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MED19 shows lower tumor expression in THCA and higher tumor expression in HNSC, LIHC, BLCA, COAD and STAD. The HNSC box plot shows higher MED19 RNA expression in tumor versus normal tissue (log2 FC = +0.740, t-test p < 0.001).
This table shows molecular features associated with MED19 in patient tissues and cancer cell lines. In patient samples, MED19 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, MED19 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and CNS.
