MED19

Across TCGA cell cohorts, MED19 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,663 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MED19-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, Spliceosomal tri-snRNP complex assembly, and Mitotic centrosome separation. Each is linked with MED19 in more than 10 cancer types. Because this analysis shows association rather than direction, both MED19-to-partner and partner-to-MED19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription initiation grouped by MED19-low versus MED19-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MED19→partner) and Y-score (partner→MED19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription initiation →	+0.049	+0.827	<.001	<.001	3	11
LUNG_SCLC	Spliceosomal tri-snRNP complex assembly →	+0.098	+0.661	<.001	<.001	3	11
LARGE_INTESTINE	Mitotic centrosome separation →	+0.111	+0.645	.001	.002	3	11
BREAST	mRNA alternative polyadenylation →	+0.091	+0.889	.003	.001	3	10
SKIN	Regulation of nucleocytoplasmic transport →	+0.053	+0.501	.002	.003	3	10
SOFT_TISSUE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.146	+0.688	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,663 associations by consensus.

Regulation of DNA-templated transcription initiation by MED19 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →