MED19

Across TCGA patient cohorts, MED19 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED19-associated genes across cancer lineages are A-Raf_pS299, HER3, and Bak. Each is linked with MED19 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED19-to-partner and partner-to-MED19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by MED19-low versus MED19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED19→partner) and Y-score (partner→MED19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.151	-3.169	.021	.019	3	1
UCEC	HER3 →	+0.550	+3.183	<.001	.010	3	1
UCEC	Bak →	+0.327	+3.169	.017	.020	3	1
UCEC	Cyclin-E2 →	+0.204	+3.009	.027	.019	3	1
UCEC	BRD4 →	+0.333	+2.818	.023	.035	2	1
UCEC	FoxM1 →	+0.314	+3.169	.027	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

A-Raf_pS299 by MED19 expression — UCEC

Explore this box plot interactively →