MED19

Across TCGA patient cohorts, MED19 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED19-associated genes across cancer lineages are E2F6P1, F8A2, and RNU6-371P. Each is linked with MED19 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED19-to-partner and partner-to-MED19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F6P1 grouped by MED19-low versus MED19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED19→partner) and Y-score (partner→MED19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	E2F6P1 →	+0.037	+4.245	<.001	.006	3	2
UCEC	F8A2 →	+0.033	+3.472	<.001	.004	3	1
COAD	RNU6-371P →	+0.596	+7.741	<.001	.009	3	1
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	1
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	1
COAD	MIR1179 →	+1.171	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

E2F6P1 by MED19 expression — UCEC

Explore this box plot interactively →