MAS1 proto-oncogene, G protein-coupled receptorGenealiases: MAS · MGRA
Q-omics provides the consensus-scored MAS1 profile across patient tissues and cancer cell-line models. MAS1 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MAS1 is differentially expressed in 10, with the highest sampling consensus in UCEC. Additionally, MAS1 protein abundance shows 10,557 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight ACC, UCEC, and HNSC as cancer lineages where MAS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAS1 survival associations across molecular data types. MAS1 RNA expression shows survival associations in the most cancer types (16), followed by mutation status (2) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAS1 RNA expression–survival associations across cancer types. High MAS1 expression shows unfavorable associations in ACC, KICH and OV, but favorable associations in HNSC, SARC and CESC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for MAS1 RNA expression.
This table summarizes MAS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 5. The strongest signals are observed in UCEC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MAS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAS1 shows lower tumor expression in UCEC, BRCA, THCA, KIRP and KIRC and higher tumor expression in COAD. The UCEC box plot shows higher MAS1 RNA expression in normal versus tumor tissue (log2 FC = −0.580, t-test p < 0.001).
This table shows molecular features associated with MAS1 in patient tissues and cancer cell lines. In patient samples, MAS1 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, MAS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LUNG_NSCLC_LUAD.
