MAS1

Across TCGA cell cohorts, MAS1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAS1-associated genes across cancer lineages are OR2C1, OR51G2, and OR52E2. Each is linked with MAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAS1-to-partner and partner-to-MAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2C1 grouped by MAS1-low versus MAS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAS1→partner) and Y-score (partner→MAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2C1 →	+0.103	+3.725	.002	.008	3	1
LARGE_INTESTINE	OR51G2 →	+0.050	+3.347	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR52E2 →	+0.341	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.207	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	DEFB133 →	+0.084	+5.228	.003	.005	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.045	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR2C1 by MAS1 expression — LARGE_INTESTINE

Explore this box plot interactively →