MAS1

Across TCGA patient cohorts, MAS1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAS1-associated genes across cancer lineages are Di-Ras3, Ku80, and MEK1. Each is linked with MAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAS1-to-partner and partner-to-MAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by MAS1-low versus MAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAS1→partner) and Y-score (partner→MAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.176	-2.459	.014	.020	3	2
UCEC	Ku80 →	+0.273	+2.472	.016	.011	3	1
UCEC	MEK1 →	+0.469	+3.584	.007	.002	3	1
UCEC	Notch1 →	+0.219	+2.459	.001	.020	3	1
UCEC	p62 Lck ligand →	+0.552	+3.179	<.001	.010	3	1
UCEC	Rab25 →	-0.483	-3.000	.002	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Di-Ras3 by MAS1 expression — UCEC

Explore this box plot interactively →