mannosidase alpha class 1C member 1Genealiases: HMIC · MAN1A3 · MAN1C · pp6318
Q-omics provides the consensus-scored MAN1C1 profile across patient tissues and cancer cell-line models. MAN1C1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, MAN1C1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, MAN1C1 RNA expression shows 25,022 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight HNSC, and KIRC as cancer lineages where MAN1C1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAN1C1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAN1C1 survival associations across molecular data types. MAN1C1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (4) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAN1C1 RNA expression–survival associations across cancer types. High MAN1C1 expression shows unfavorable associations in KIRP, UVM and LGG, but favorable associations in HNSC, CESC and SKCM. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for MAN1C1 RNA expression.
This table summarizes MAN1C1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 9. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for MAN1C1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAN1C1 shows lower tumor expression in KIRC, KIRP, THCA, LUAD, COAD and LIHC. The KIRC box plot shows higher MAN1C1 RNA expression in normal versus tumor tissue (log2 FC = −2.706, t-test p < 0.001).
This table shows molecular features associated with MAN1C1 in patient tissues and cancer cell lines. In patient samples, MAN1C1 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, MAN1C1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and SOFT_TISSUE.
