MAN1C1

Across TCGA patient cohorts, MAN1C1 mutation is significantly associated with the RNA expression of many other genes, with 1,124 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN1C1-associated genes across cancer lineages are LINC00376, RCC2P1, and MTCO2P21. Each is linked with MAN1C1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN1C1-to-partner and partner-to-MAN1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00376 grouped by MAN1C1-low versus MAN1C1-high in MESO.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1C1→partner) and Y-score (partner→MAN1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	LINC00376 →	+0.073	+5.321	<.001	.005	3	2
MESO	RCC2P1 →	+0.035	+5.754	<.001	.002	3	2
MESO	MTCO2P21 →	+0.071	+5.754	<.001	.002	3	2
MESO	LINC00564 →	+0.046	+6.357	<.001	<.001	3	2
UCEC	ESS2 →	+0.281	+3.584	.004	.002	3	2
UCEC	GZMH →	+0.987	+2.606	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,124 associations by consensus.

LINC00376 by MAN1C1 expression — MESO

Explore this box plot interactively →