MAN1C1

Across TCGA cell cohorts, MAN1C1 mutation is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAN1C1-associated genes across cancer lineages are OXT, AVPR1B, and FOXB2. Each is linked with MAN1C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN1C1-to-partner and partner-to-MAN1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by MAN1C1-low versus MAN1C1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1C1→partner) and Y-score (partner→MAN1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	1
SKIN	AVPR1B →	+0.006	+5.415	.007	.004	3	1
SKIN	FOXB2 →	+0.036	+5.415	<.001	.004	3	1
LARGE_INTESTINE	GCAT →	+1.134	+3.212	.007	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.503	+3.837	<.001	<.001	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.118	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

OXT by MAN1C1 expression — SKIN

Explore this box plot interactively →