Q-omics provides the consensus-scored MALL profile across patient tissues and cancer cell-line models. MALL expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MALL is differentially expressed in 12, with the highest sampling consensus in COAD. Additionally, MALL RNA expression shows 17,410 significant gene co-expression associations, with the highest sampling consensus in DLBC. Together, these results highlight KIRC, COAD, and DLBC as cancer lineages where MALL shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MALL — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MALL survival associations across molecular data types. MALL RNA expression shows survival associations in the most cancer types (22), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MALL RNA expression–survival associations across cancer types. High MALL expression shows unfavorable associations in UVM, MESO, BLCA and KIRP, but favorable associations in KIRC and LUAD. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for MALL RNA expression.
This table summarizes MALL tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for MALL. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MALL shows lower tumor expression in COAD, READ, LUSC and BRCA and higher tumor expression in KIRC and PAAD. The COAD box plot shows higher MALL RNA expression in normal versus tumor tissue (log2 FC = −2.040, t-test p < 0.001).
This table shows molecular features associated with MALL in patient tissues and cancer cell lines. In patient samples, MALL shows the broadest associations at the RNA and protein expression levels, with DLBC recurring as the lineage with the largest associated feature set. In cancer cell lines, MALL RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUSC, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LUNG_NSCLC_LUAD.
