MALL

Across TCGA cell cohorts, MALL mutation is significantly associated with the mutation status of many other genes, with 180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MALL-associated genes across cancer lineages are OR1I1, CRISP3, and SRP54. Each is linked with MALL in more than 1 cancer types. Because this analysis shows association rather than direction, both MALL-to-partner and partner-to-MALL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1I1 grouped by MALL-low versus MALL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MALL→partner) and Y-score (partner→MALL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR1I1 →	+5.523	+5.523	.003	.003	1	1
LARGE_INTESTINE	CRISP3 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	SRP54 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	RIMS4 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	CSNK2A1 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	XIAP →	+4.523	+5.087	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

OR1I1 by MALL expression — LARGE_INTESTINE

Explore this box plot interactively →