limbic system associated membrane proteinGenealiases: IGLON3 · LAMP
Q-omics provides the consensus-scored LSAMP profile across patient tissues and cancer cell-line models. LSAMP expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in CHOL. Among the 18 cancer types available for tumor–normal comparison, LSAMP is differentially expressed in 9, with the highest sampling consensus in KIRC. Additionally, LSAMP protein abundance shows 25,930 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight CHOL, KIRC, and GBM as cancer lineages where LSAMP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LSAMP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LSAMP survival associations across molecular data types. LSAMP RNA expression shows survival associations in the most cancer types (23), followed by mutation status (6) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LSAMP RNA expression–survival associations across cancer types. High LSAMP expression shows unfavorable associations in UVM and THCA, but favorable associations in CHOL, HNSC, ACC and LUAD. The CHOL Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify CHOL as the clearest survival context for LSAMP RNA expression.
This table summarizes LSAMP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for LSAMP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LSAMP shows lower tumor expression in KIRC, LUSC, LUAD, UCEC and KIRP and higher tumor expression in HNSC. The KIRC box plot shows higher LSAMP RNA expression in normal versus tumor tissue (log2 FC = −1.762, t-test p < 0.001).
This table shows molecular features associated with LSAMP in patient tissues and cancer cell lines. In patient samples, LSAMP shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, LSAMP RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and SKIN.
