Across TCGA cell cohorts, LSAMP mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible LSAMP-associated genes across cancer lineages are C1QC, MAGEB5, and DEUP1. Each is linked with LSAMP in more than 1 cancer types. Because this analysis shows association rather than direction, both LSAMP-to-partner and partner-to-LSAMP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSAMP→partner) and Y-score (partner→LSAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C1QC →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	DEUP1 →	+0.341	+3.832	<.001	.001	3	1
LARGE_INTESTINE	LIPJ →	+0.048	+3.006	.003	.006	3	1
LUNG_SCLC	CT47A6 →	+1.069	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	ZNF705G →	+0.003	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

LSAMP survival (RNA) · tumor vs normal (RNA) · all LSAMP data types