Q-omics provides the consensus-scored DEUP1 profile across patient tissues and cancer cell-line models. DEUP1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, DEUP1 is differentially expressed in 7, with the highest sampling consensus in THCA. Additionally, DEUP1 RNA expression shows 16,160 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight ACC, THCA, and THYM as cancer lineages where DEUP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DEUP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DEUP1 survival associations across molecular data types. DEUP1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DEUP1 RNA expression–survival associations across cancer types. High DEUP1 expression shows unfavorable associations in UVM, KICH and BRCA, but favorable associations in ACC, HNSC and LGG. The ACC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for DEUP1 RNA expression.
This table summarizes DEUP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for DEUP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DEUP1 shows lower tumor expression in THCA, KICH, KIRP, KIRC and UCEC and higher tumor expression in BRCA. The THCA box plot shows higher DEUP1 RNA expression in normal versus tumor tissue (log2 FC = −0.714, t-test p < 0.001).
This table shows molecular features associated with DEUP1 in patient tissues and cancer cell lines. In patient samples, DEUP1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, DEUP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and SKIN.
