DEUP1

Across TCGA cell cohorts, DEUP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,615 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DEUP1-associated GO terms across cancer lineages are Regulation of ATP-dependent activity, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway, and Post-translational protein targeting to membrane, translocation. Each is linked with DEUP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DEUP1-to-partner and partner-to-DEUP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of ATP-dependent activity grouped by DEUP1-low versus DEUP1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEUP1→partner) and Y-score (partner→DEUP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of ATP-dependent activity →	+0.071	+0.161	.001	.006	3	6
OVARY	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.062	-0.584	<.001	.002	3	6
OVARY	Post-translational protein targeting to membrane, translocation →	+0.093	+0.508	<.001	<.001	3	5
OVARY	Cilium movement →	-0.041	-0.340	.001	.005	3	5
OVARY	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-0.065	-0.640	<.001	<.001	3	5
LUNG_NSCLC_LUAD	Protein folding →	+0.037	+0.315	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,615 associations by consensus.

Regulation of ATP-dependent activity by DEUP1 expression — PANCREAS

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