DEUP1

Across TCGA patient cohorts, DEUP1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEUP1-associated genes across cancer lineages are Rab25, Caspase-7-cleavedD198, and Notch1. Each is linked with DEUP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEUP1-to-partner and partner-to-DEUP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by DEUP1-low versus DEUP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEUP1→partner) and Y-score (partner→DEUP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.397	-2.415	<.001	.003	3	3
UCEC	Caspase-7-cleavedD198 →	+0.421	+2.341	.031	.003	3	3
UCEC	Notch1 →	+0.141	+1.817	.002	.015	3	2
UCEC	Shc_pY317 →	-0.174	-1.925	<.001	.004	3	2
UCEC	TIGAR →	+0.112	+1.418	.025	.012	3	2
UCEC	cIAP →	+0.089	+1.710	.048	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Rab25 by DEUP1 expression — UCEC

Explore this box plot interactively →