DEUP1

Across TCGA cell cohorts, DEUP1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DEUP1-associated genes across cancer lineages are MS4A4A, TMEM95, and C16orf96. Each is linked with DEUP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEUP1-to-partner and partner-to-DEUP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by DEUP1-low versus DEUP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEUP1→partner) and Y-score (partner→DEUP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.179	+3.000	<.001	.006	3	2
LARGE_INTESTINE	TMEM95 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
SKIN	HMHB1 →	+0.046	+4.437	<.001	.004	3	1
SKIN	CRYAA →	+0.052	+3.930	<.001	.003	3	1
SKIN	LCE4A →	+0.038	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MS4A4A by DEUP1 expression — LARGE_INTESTINE

Explore this box plot interactively →