Across TCGA patient cohorts, LSAMP mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSAMP-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and c-Jun_pS73. Each is linked with LSAMP in more than 2 cancer types. Because this analysis shows association rather than direction, both LSAMP-to-partner and partner-to-LSAMP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSAMP→partner) and Y-score (partner→LSAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.594	+2.087	.005	.005	3	3
LUSC	Caspase-7-cleavedD198 →	+0.663	+3.018	.002	.017	3	2
LUSC	c-Jun_pS73 →	-0.209	-3.000	.007	.035	2	3
UCEC	FASN →	+0.339	+2.459	.024	.019	3	2
UCEC	Tuberin →	+0.307	+2.459	.002	.018	3	2
UCEC	4E-BP1 →	+0.246	+3.169	.017	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

LSAMP survival (RNA) · tumor vs normal (RNA) · all LSAMP data types