lunapark, ER junction formation factorGenealiases: KIAA1715 · LNP · LNP1 · NEDEHCC · Ul · ulnaless
Q-omics provides the consensus-scored LNPK profile across patient tissues and cancer cell-line models. LNPK expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, LNPK is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, LNPK RNA expression shows 20,306 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KICH, KIRC, and ACC as cancer lineages where LNPK shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LNPK — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LNPK survival associations across molecular data types. LNPK RNA expression shows survival associations in the most cancer types (20), followed by mutation status (6) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LNPK RNA expression–survival associations across cancer types. High LNPK expression shows unfavorable associations in KICH, MESO, KIRP and ACC, but favorable associations in KIRC and LUSC. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for LNPK RNA expression.
This table summarizes LNPK tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for LNPK. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LNPK shows higher tumor expression in KIRC, HNSC, KIRP, LUAD, BLCA and LIHC. The KIRC box plot shows higher LNPK RNA expression in tumor versus normal tissue (log2 FC = +0.880, t-test p < 0.001).
This table shows molecular features associated with LNPK in patient tissues and cancer cell lines. In patient samples, LNPK shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, LNPK RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUSC and BLOOD_Leukemia.
