LNPK

Across TCGA pan-cancer cohorts, LNPK RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LNPK data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher LNPK RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LNPK expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

KICH, MESO, and KIRC are the cancer types where LNPK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.718	1.000	<.001	86	view →
MESO	OS	Median	All	0.287	0.474	.002	70	view →
KIRC	DFS	Tertile	All	0.719	0.521	<.001	69	view →
LUSC	DFS	Tertile	All	0.813	0.681	.001	53	view →
KIRP	DFS	Quartile	All	0.873	0.990	.001	50	view →
ACC	DFS	Median	All	0.405	0.753	<.001	49	view →
LIHC	OS	Median	All	0.362	0.585	<.001	35	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	29	view →
PAAD	OS	Quartile	All	0.321	0.593	.014	19	view →
UCS	DFS	Tertile	IV	0.860	0.364	.024	18	view →
THCA	OS	Median	All	0.983	0.997	.006	17	view →
CESC	DFS	Median	All	0.444	0.661	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

LNPK–KICH (OS)

Open the KICH breakdown →