LNPK

Across TCGA pan-cancer cohorts, LNPK mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LNPK data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LNPK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LNPK expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

HNSC, LSCC, and COAD are the cancer types where LNPK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.315	0.832	.024	18	view →
LSCC	OS	Median	All	1.000	0.926	.016	7	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.885	.027	6	view →
UCEC	DFS	Median	II,III,IV	0.865	0.550	.027	4	view →
LUAD	DFS	Tertile	All	0.578	0.934	.016	4	view →
PDAC	DFS	Quartile	All	0.695	0.849	.024	3	view →
GBM	OS	Tertile	All	0.692	0.981	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LNPK–HNSC (DFS)

Open the HNSC breakdown →