Q-omics provides the consensus-scored LINGO3 profile across patient tissues and cancer cell-line models. LINGO3 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, LINGO3 is differentially expressed in 6, with the highest sampling consensus in KIRC. Additionally, LINGO3 RNA expression shows 14,868 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KIRC as cancer lineages where LINGO3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINGO3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINGO3 survival associations across molecular data types. LINGO3 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINGO3 RNA expression–survival associations across cancer types. High LINGO3 expression shows unfavorable associations in UVM and LGG, but favorable associations in HNSC, LUAD, SKCM and PAAD. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for LINGO3 RNA expression.
This table summarizes LINGO3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for LINGO3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINGO3 shows lower tumor expression in LUSC and higher tumor expression in KIRC, KIRP, BRCA, PRAD and CHOL. The KIRC box plot shows higher LINGO3 RNA expression in tumor versus normal tissue (log2 FC = +0.472, t-test p < 0.001).
This table shows molecular features associated with LINGO3 in patient tissues and cancer cell lines. In patient samples, LINGO3 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, LINGO3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Leukemia.
