Across TCGA patient cohorts, LINGO3 mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LINGO3-associated genes across cancer lineages are RPL17-C18orf32, SCG5-AS1, and CHURC1-FNTB. Each is linked with LINGO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO3-to-partner and partner-to-LINGO3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO3→partner) and Y-score (partner→LINGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL17-C18orf32 →	+0.090	+3.232	<.001	.002	3	2
COAD	SCG5-AS1 →	+0.277	+3.669	<.001	.003	3	2
COAD	CHURC1-FNTB →	+0.096	+3.865	<.001	.002	3	2
LUSC	RNU6-455P →	+0.461	+4.857	<.001	<.001	3	2
BLCA	OR5P4P →	+0.091	+3.788	.005	.009	3	2
UCEC	RNU6ATAC30P →	+0.455	+3.517	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

Exploration

LINGO3 survival (RNA) · tumor vs normal (RNA) · all LINGO3 data types