Across TCGA patient cohorts, LINGO3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LINGO3-associated genes across cancer lineages are PI3K-p85, PTEN, and Caspase-7-cleavedD198. Each is linked with LINGO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO3-to-partner and partner-to-LINGO3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO3→partner) and Y-score (partner→LINGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PI3K-p85 →	+0.181	+2.815	.021	.036	3	1
COAD	PTEN →	+0.184	+2.815	.016	.036	3	1
COAD	Caspase-7-cleavedD198 →	+1.116	+2.815	.010	.036	3	1
COAD	p38-MAPK →	+0.238	+2.815	.013	.036	2	1
COAD	Smad4 →	+0.164	+2.815	.024	.036	1	2
COAD	G6PD →	+0.282	+2.815	.006	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

LINGO3 survival (RNA) · tumor vs normal (RNA) · all LINGO3 data types