Across TCGA cell cohorts, LINGO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,200 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LINGO3-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Positive regulation of intracellular steroid hormone receptor signaling pathway, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with LINGO3 in more than 11 cancer types. Because this analysis shows association rather than direction, both LINGO3-to-partner and partner-to-LINGO3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO3→partner) and Y-score (partner→LINGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.095	+0.717	<.001	.006	3	12
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.157	+0.934	.001	.003	3	12
SKIN	Negative regulation of transcription initiation by RNA polymerase II →	+0.054	+0.032	.009	.006	3	11
LARGE_INTESTINE	Negative regulation of myoblast fusion →	+0.082	+0.206	<.001	.006	3	11
SKIN	Negative regulation of DNA-templated transcription initiation →	+0.054	+0.032	.009	.006	3	11
OESOPHAGUS	Nucleic acid catabolic process →	+0.049	+0.445	<.001	.009	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,200 associations by consensus.

Exploration

LINGO3 survival (RNA) · tumor vs normal (RNA) · all LINGO3 data types