Across TCGA cell cohorts, LINGO3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LINGO3-associated genes across cancer lineages are RESP18, GUCA1C, and MYOCD. Each is linked with LINGO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO3-to-partner and partner-to-LINGO3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO3→partner) and Y-score (partner→LINGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RESP18 →	+0.029	+4.415	<.001	.007	3	1
BLOOD_Leukemia	GUCA1C →	+0.023	+4.384	<.001	.006	3	1
BLOOD_Leukemia	MYOCD →	+1.101	+4.108	<.001	.009	3	1
BLOOD_Leukemia	CYP39A1 →	+0.114	+3.769	.009	.008	3	1
BLOOD_Leukemia	AQP12A →	+0.091	+4.269	<.001	.002	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

LINGO3 survival (RNA) · tumor vs normal (RNA) · all LINGO3 data types