Across TCGA cell cohorts, LINGO3 mutation is significantly associated with the mutation status of many other genes, with 2,167 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LINGO3-associated genes across cancer lineages are LOXL3, MYBBP1A, and DACH1. Each is linked with LINGO3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LINGO3-to-partner and partner-to-LINGO3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO3→partner) and Y-score (partner→LINGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LOXL3 →	+3.787	+4.669	<.001	<.001	1	4
BLOOD_Leukemia	MYBBP1A →	+3.176	+5.225	<.001	<.001	1	4
BLOOD_Leukemia	DACH1 →	+4.050	+3.870	.002	.002	1	3
BLOOD_Lymphoma	SF3A1 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Leukemia	ASAP1 →	+5.050	+4.700	<.001	<.001	1	3
BLOOD_Leukemia	BRSK1 →	+4.050	+4.260	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,167 associations by consensus.

Exploration

LINGO3 survival (RNA) · tumor vs normal (RNA) · all LINGO3 data types