Q-omics provides the consensus-scored LENEP profile across patient tissues and cancer cell-line models. LENEP expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, LENEP is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, LENEP RNA expression shows 15,403 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UVM, THCA, and THYM as cancer lineages where LENEP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LENEP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LENEP survival associations across molecular data types. LENEP RNA expression shows survival associations in the most cancer types (25), followed by mutation status (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LENEP RNA expression–survival associations across cancer types. High LENEP expression shows unfavorable associations in UVM, THCA, KIRC, KIRP and LIHC, but favorable associations in HNSC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for LENEP RNA expression.
This table summarizes LENEP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for LENEP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LENEP shows lower tumor expression in THCA and higher tumor expression in HNSC, LIHC, LUSC, COAD and BRCA. The THCA box plot shows higher LENEP RNA expression in normal versus tumor tissue (log2 FC = −0.344, t-test p < 0.001).
This table shows molecular features associated with LENEP in patient tissues and cancer cell lines. In patient samples, LENEP shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, LENEP RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BREAST.
