LENEP

Across TCGA pan-cancer cohorts, LENEP RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LENEP data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher LENEP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LENEP expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

UVM, HNSC, and THCA are the cancer types where LENEP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.541	0.833	<.001	125	view →
HNSC	OS	Median	All	0.807	0.694	<.001	59	view →
THCA	DFS	Median	III,IV	0.724	0.903	<.001	50	view →
KIRC	DFS	Tertile	III,IV	0.373	0.573	.007	44	view →
KIRP	DFS	Tertile	All	0.522	0.797	.003	43	view →
LIHC	DFS	Quartile	All	0.439	0.597	.004	36	view →
CHOL	DFS	Quartile	II,III,IV	0.119	0.845	.006	27	view →
SCLC	DFS	Tertile	All	0.852	0.228	.003	25	view →
ESCA	OS	Quartile	III,IV	0.720	0.298	.010	22	view →
ACC	DFS	Tertile	III,IV	0.694	0.275	.004	18	view →
PRAD	DFS	Quartile	All	0.792	0.908	.007	16	view →
STAD	OS	Median	All	0.738	0.593	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LENEP–UVM (DFS)

Open the UVM breakdown →