LENEP

Across TCGA pan-cancer cohorts, LENEP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LENEP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LENEP RNA is repressed in tumor relative to normal tissue. In most cancer types LENEP is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, HNSC, and LIHC are the cancer types where LENEP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LENEP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.344	<.001	9	view →
HNSC	All	II,III,IV	+0.086	.005	8	view →
LIHC	Male	All	+0.135	<.001	7	view →
LUSC	All	All	+0.294	<.001	5	view →
COAD	All	All	+0.172	.002	5	view →
BRCA	All	All	+0.257	<.001	4	view →
STAD	Male	All	+0.211	.008	3	view →
BLCA	All	All	+0.170	.030	3	view →
CHOL	All	All	+0.533	.020	2	view →
PRAD	All	All	+0.242	.001	2	view →
LUAD	All	All	+0.158	.020	2	view →
KIRP	Male	All	−0.125	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LENEP–THCA

Open the THCA breakdown →