low density lipoprotein receptor adaptor protein 1Genealiases: ARH · ARH1 · ARH2 · FHCB1 · FHCB2 · FHCL4
Q-omics provides the consensus-scored LDLRAP1 profile across patient tissues and cancer cell-line models. LDLRAP1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in LAML. Among the 18 cancer types available for tumor–normal comparison, LDLRAP1 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, LDLRAP1 protein abundance shows 22,963 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight LAML, KIRC, and HNSC as cancer lineages where LDLRAP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LDLRAP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LDLRAP1 survival associations across molecular data types. LDLRAP1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (4) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LDLRAP1 RNA expression–survival associations across cancer types. High LDLRAP1 expression shows unfavorable associations in LAML, LGG and KICH, but favorable associations in ESCA, CESC and PAAD. The LAML Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify LAML as the clearest survival context for LDLRAP1 RNA expression.
This table summarizes LDLRAP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for LDLRAP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LDLRAP1 shows lower tumor expression in KIRC, KICH, KIRP and COAD and higher tumor expression in HNSC and STAD. The KIRC box plot shows higher LDLRAP1 RNA expression in normal versus tumor tissue (log2 FC = −0.749, t-test p < 0.001).
This table shows molecular features associated with LDLRAP1 in patient tissues and cancer cell lines. In patient samples, LDLRAP1 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, LDLRAP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and CNS.
