LDLRAP1

Across TCGA cell cohorts, LDLRAP1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDLRAP1-associated genes across cancer lineages are CASP14, C4orf45, and HTRA3. Each is linked with LDLRAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAP1-to-partner and partner-to-LDLRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CASP14 grouped by LDLRAP1-low versus LDLRAP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAP1→partner) and Y-score (partner→LDLRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CASP14 →	+0.069	+2.648	.006	.008	3	1
LARGE_INTESTINE	C4orf45 →	+0.311	+3.011	.005	.003	3	1
LARGE_INTESTINE	HTRA3 →	+0.144	+3.040	.006	.002	3	1
LARGE_INTESTINE	ATP4B →	+0.037	+2.444	<.001	.008	3	1
LARGE_INTESTINE	CCER1 →	+0.009	+2.977	<.001	.006	3	1
LARGE_INTESTINE	SLC12A3 →	+0.334	+3.674	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CASP14 by LDLRAP1 expression — LARGE_INTESTINE

Explore this box plot interactively →