LDLRAP1

Across TCGA patient cohorts, LDLRAP1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDLRAP1-associated genes across cancer lineages are ERK2, MEK1, and MSH6. Each is linked with LDLRAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAP1-to-partner and partner-to-LDLRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LDLRAP1-low versus LDLRAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAP1→partner) and Y-score (partner→LDLRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.149	+1.502	.035	.030	3	1
UCEC	MEK1 →	+0.308	+1.502	.021	.030	3	1
UCEC	MSH6 →	-0.434	-2.000	<.001	.029	3	1
UCEC	p62 Lck ligand →	+0.413	+1.847	<.001	.008	3	1
UCEC	Annexin-1 →	+0.564	+2.242	.003	.005	3	1
UCEC	TIGAR →	+0.193	+1.529	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by LDLRAP1 expression — UCEC

Explore this box plot interactively →