LDLRAP1

Across TCGA pan-cancer cohorts, LDLRAP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LDLRAP1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LDLRAP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LDLRAP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where LDLRAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.683	0.263	<.001	24	view →
UCEC	OS	Tertile	All	1.000	0.824	.007	16	view →
CCRCC	OS	Median	II,III,IV	0.339	1.000	.003	7	view →
HNSC	OS	Tertile	All	0.916	0.754	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LDLRAP1–PDAC (DFS)

Open the PDAC breakdown →