LDLRAP1

Across TCGA cell cohorts, LDLRAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,251 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LDLRAP1-associated GO terms across cancer lineages are Positive regulation of low-density lipoprotein particle clearance, Regulation of protein localization to cell periphery, and Vacuole organization. Each is linked with LDLRAP1 in more than 13 cancer types. Because this analysis shows association rather than direction, both LDLRAP1-to-partner and partner-to-LDLRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of low-density lipoprotein particle clearance grouped by LDLRAP1-low versus LDLRAP1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAP1→partner) and Y-score (partner→LDLRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of low-density lipoprotein particle clearance →	-0.179	-1.309	.001	.002	2	14
LUNG_NSCLC_LUSC	Regulation of protein localization to cell periphery →	+0.091	+0.877	<.001	.004	3	13
BONE	Vacuole organization →	+0.059	+1.073	<.001	.004	2	11
CNS	Positive regulation of type 2 mitophagy →	+0.115	+0.634	<.001	<.001	3	10
SKIN	Endosomal transport →	+0.040	+0.814	.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to plasma membrane →	+0.090	+0.947	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,251 associations by consensus.

Positive regulation of low-density lipoprotein particle clearance by LDLRAP1 expression — LUNG_SCLC

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