LDLRAP1

Across TCGA patient cohorts, LDLRAP1 mutation is significantly associated with the RNA expression of many other genes, with 1,143 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDLRAP1-associated genes across cancer lineages are LINC02307, MIR4694, and RNA5SP411. Each is linked with LDLRAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAP1-to-partner and partner-to-LDLRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02307 grouped by LDLRAP1-low versus LDLRAP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAP1→partner) and Y-score (partner→LDLRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02307 →	+0.339	+5.790	<.001	.003	3	2
KIRP	MIR4694 →	+0.594	+5.770	<.001	.003	3	2
UCEC	RNA5SP411 →	+0.759	+1.628	.001	.005	3	2
UCEC	RNA5SP86 →	+0.304	+2.162	<.001	.006	3	2
UCEC	ADH5P2 →	+0.080	+1.784	.006	.003	3	2
UCEC	AP1B1P1 →	+0.068	+1.588	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,143 associations by consensus.

LINC02307 by LDLRAP1 expression — COAD

Explore this box plot interactively →