LDLRAP1

Across TCGA patient cohorts, LDLRAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,120 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LDLRAP1-associated genes across cancer lineages are VAMP3, PPFIA4, and PBK. Each is linked with LDLRAP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both LDLRAP1-to-partner and partner-to-LDLRAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDLRAP1 versus VAMP3 in BRCA, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAP1→partner) and Y-score (partner→LDLRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VAMP3 →	+0.473	+0.286	<.001	<.001	3	6
BRCA	PPFIA4 →	-0.841	-0.270	.001	.004	3	6
GBM	PBK →	-1.186	-0.630	<.001	<.001	3	6
BRCA	CDC42 →	+0.534	+0.375	<.001	<.001	3	5
OV	CAPZB →	+0.435	+0.450	.002	<.001	3	5
BRCA	C7 →	+1.444	+0.320	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,120 associations by consensus.

LDLRAP1 vs VAMP3 — BRCA

Explore this scatter interactively →