Q-omics provides the consensus-scored LAMB4 profile across patient tissues and cancer cell-line models. LAMB4 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, LAMB4 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, LAMB4 protein abundance shows 29,486 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight UVM, KIRC, and LSCC as cancer lineages where LAMB4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LAMB4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LAMB4 survival associations across molecular data types. LAMB4 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (8) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LAMB4 RNA expression–survival associations across cancer types. High LAMB4 expression shows unfavorable associations in UVM, LGG, SKCM and LUSC, but favorable associations in SCLC and PAAD. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify UVM as the clearest survival context for LAMB4 RNA expression.
This table summarizes LAMB4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 10. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for LAMB4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LAMB4 shows lower tumor expression in KIRC, HNSC, KIRP and THCA and higher tumor expression in LIHC and UCEC. The KIRC box plot shows higher LAMB4 RNA expression in normal versus tumor tissue (log2 FC = −0.925, t-test p < 0.001).
This table shows molecular features associated with LAMB4 in patient tissues and cancer cell lines. In patient samples, LAMB4 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, LAMB4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and LARGE_INTESTINE.
