LAMB4

Across TCGA cell cohorts, LAMB4 mutation is significantly associated with the RNA expression of many other genes, with 1,266 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMB4-associated genes across cancer lineages are GAS2L2, CCDC184, and TLE6. Each is linked with LAMB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMB4-to-partner and partner-to-LAMB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAS2L2 grouped by LAMB4-low versus LAMB4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB4→partner) and Y-score (partner→LAMB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GAS2L2 →	+0.428	+2.719	<.001	.005	3	3
BLOOD_Leukemia	CCDC184 →	+0.313	+2.697	<.001	.008	3	3
LARGE_INTESTINE	TLE6 →	+0.795	+1.850	.001	.006	3	3
LARGE_INTESTINE	MAD2L2 →	+0.645	+1.850	.007	.006	3	3
LARGE_INTESTINE	PPAN →	+0.559	+1.850	.001	.006	3	3
LARGE_INTESTINE	AOC2 →	+0.590	+3.321	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,266 associations by consensus.

GAS2L2 by LAMB4 expression — SOFT_TISSUE

Explore this box plot interactively →