LAMB4

Across TCGA patient cohorts, LAMB4 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMB4-associated genes across cancer lineages are Caspase-7-cleavedD198, HER2_pY1248, and MEK1. Each is linked with LAMB4 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMB4-to-partner and partner-to-LAMB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LAMB4-low versus LAMB4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB4→partner) and Y-score (partner→LAMB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.152	+3.016	<.001	.018	3	5
SKCM	HER2_pY1248 →	-0.091	-1.678	.034	.018	3	3
UCEC	MEK1 →	+0.393	+1.807	<.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.128	-1.289	.004	.021	3	3
UCEC	4E-BP1 →	+0.293	+1.999	<.001	<.001	3	3
STAD	PCNA →	+0.455	+3.000	.002	.036	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Caspase-7-cleavedD198 by LAMB4 expression — COAD

Explore this box plot interactively →