kallikrein related peptidase 12Genealiases: KLK-L5 · KLKL5
Q-omics provides the consensus-scored KLK12 profile across patient tissues and cancer cell-line models. KLK12 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, KLK12 is differentially expressed in 6, with the highest sampling consensus in COAD. Additionally, KLK12 RNA expression shows 11,854 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, COAD, and THYM as cancer lineages where KLK12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KLK12 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KLK12 survival associations across molecular data types. KLK12 RNA expression shows survival associations in the most cancer types (17), followed by mutation status (12) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KLK12 RNA expression–survival associations across cancer types. High KLK12 expression shows unfavorable associations in KIRC, SKCM and KICH, but favorable associations in BRCA, THCA and ESCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for KLK12 RNA expression.
This table summarizes KLK12 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6, while mass-spec protein shows differences in 1. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for KLK12. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KLK12 shows lower tumor expression in HNSC and higher tumor expression in COAD, THCA, LUSC, PRAD and UCEC. The COAD box plot shows higher KLK12 RNA expression in tumor versus normal tissue (log2 FC = +2.477, t-test p < 0.001).
This table shows molecular features associated with KLK12 in patient tissues and cancer cell lines. In patient samples, KLK12 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, KLK12 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SKIN and SOFT_TISSUE.
