Across TCGA patient cohorts, KLK12 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLK12-associated genes across cancer lineages are eEF2, TFRC, and GAPDH. Each is linked with KLK12 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK12-to-partner and partner-to-KLK12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK12→partner) and Y-score (partner→KLK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.498	+2.000	<.001	.029	3	3
UCEC	TFRC →	+0.584	+2.999	.005	.035	3	3
UCEC	GAPDH →	+0.598	+2.000	.004	.010	3	2
UCEC	mTOR_pS2448 →	-0.160	-2.095	.006	.017	3	2
UCEC	PCNA →	+0.322	+2.000	<.001	.010	3	2
UCEC	Shc_pY317 →	-0.211	-2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

KLK12 survival (RNA) · tumor vs normal (RNA) · all KLK12 data types