Across TCGA cell cohorts, KLK12 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLK12-associated genes across cancer lineages are FABP12, TECTB, and C10orf53. Each is linked with KLK12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK12-to-partner and partner-to-KLK12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK12→partner) and Y-score (partner→KLK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FABP12 →	+0.189	+4.981	<.001	.008	3	1
BLOOD_Lymphoma	TECTB →	+0.063	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	C10orf53 →	+0.021	+4.867	.001	.009	3	1
LARGE_INTESTINE	RGPD4 →	+0.034	+4.518	.003	<.001	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

KLK12 survival (RNA) · tumor vs normal (RNA) · all KLK12 data types