Across TCGA patient cohorts, KLK12 protein abundance is significantly associated with the RNA expression of many other genes, with 3,379 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KLK12-associated genes across cancer lineages are DOK5, ZDHHC15, and RASAL1. Each is linked with KLK12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLK12-to-partner and partner-to-KLK12 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK12→partner) and Y-score (partner→KLK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DOK5 →	-0.717	-0.786	.002	.002	3	2
LUAD	ZDHHC15 →	-0.678	-0.842	<.001	.001	3	2
LUAD	RASAL1 →	+0.958	+1.020	.003	.001	3	2
HNSC	ANOS1 →	-0.782	-0.604	<.001	<.001	3	2
HNSC	ST8SIA4 →	-0.571	-0.502	.004	.005	3	2
LUAD	HEMK1 →	-0.527	-0.888	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,379 associations by consensus.

Exploration

KLK12 survival (RNA) · tumor vs normal (RNA) · all KLK12 data types