potassium sodium-activated channel subfamily T member 1Genealiases: DEE14 · EIEE14 · ENFL5 · KCa4.1 · KNa1.1 · SLACK
Q-omics provides the consensus-scored KCNT1 profile across patient tissues and cancer cell-line models. KCNT1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, KCNT1 is differentially expressed in 7, with the highest sampling consensus in KIRC. Additionally, KCNT1 protein abundance shows 20,812 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight UCEC, KIRC, and LUAD as cancer lineages where KCNT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNT1 survival associations across molecular data types. KCNT1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (13) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNT1 RNA expression–survival associations across cancer types. High KCNT1 expression shows unfavorable associations in UCEC, COAD, OV and KIRC, but favorable associations in ACC and BLCA. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for KCNT1 RNA expression.
This table summarizes KCNT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for KCNT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNT1 shows lower tumor expression in HNSC and LUSC and higher tumor expression in KIRC, LIHC, COAD and CHOL. The KIRC box plot shows higher KCNT1 RNA expression in tumor versus normal tissue (log2 FC = +0.040, t-test p < 0.001).
This table shows molecular features associated with KCNT1 in patient tissues and cancer cell lines. In patient samples, KCNT1 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNT1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and LARGE_INTESTINE.
