KCNT1

Across TCGA pan-cancer cohorts, KCNT1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated KCNT1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher KCNT1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated KCNT1 expression acts as an unfavorable survival marker, although some lineages such as STAD and COAD show a favorable association.

STAD, LIHC, and SCLC are the cancer types where KCNT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.856	0.401	.025	13	view →
LIHC	DFS	Median	All	0.168	0.562	<.001	13	view →
SCLC	OS	Median	IV	0.137	0.548	.004	12	view →
UCEC	OS	Median	IV	0.253	0.793	<.001	12	view →
LUSC	DFS	Median	III,IV	0.272	0.671	.010	9	view →
KIRP	OS	Median	All	0.618	0.948	.016	6	view →
PCPG	DFS	Median	All	0.063	0.924	<.001	6	view →
LUAD	DFS	Median	II,III,IV	0.178	0.721	.008	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →
KICH	DFS	Median	All	0.162	0.862	.014	5	view →
DLBC	OS	Median	All	0.613	0.945	.049	3	view →
LGG	DFS	Median	All	0.224	0.728	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

KCNT1–STAD (OS)

Open the STAD breakdown →