KCNT1

Across TCGA cell cohorts, KCNT1 mutation is significantly associated with the RNA expression of many other genes, with 459 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNT1-associated genes across cancer lineages are TNRC6B, RPF1, and ENOPH1. Each is linked with KCNT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNT1-to-partner and partner-to-KCNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNRC6B grouped by KCNT1-low versus KCNT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNT1→partner) and Y-score (partner→KCNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNRC6B →	+0.632	+3.234	.006	.004	3	2
LARGE_INTESTINE	RPF1 →	+0.714	+3.409	<.001	<.001	3	2
LARGE_INTESTINE	ENOPH1 →	+0.540	+3.502	.001	.001	3	2
LARGE_INTESTINE	C8orf37 →	+0.497	+3.169	<.001	.009	3	2
LARGE_INTESTINE	ZNF620 →	+0.654	+3.502	<.001	.001	3	2
LARGE_INTESTINE	ZNF771 →	+0.617	+3.234	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 459 associations by consensus.

TNRC6B by KCNT1 expression — LARGE_INTESTINE

Explore this box plot interactively →